Brain-derived neurotrophic factor: role in depression and suicide
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چکیده
منابع مشابه
Brain-derived neurotrophic factor: role in depression and suicide
Depression and suicidal behavior have recently been shown to be associated with disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, plays an important role in the maintenance and survival of neurons and in synaptic plasticity. Several lines of evidence suggest that BDNF is involved in depression, such that the expr...
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Increasing evidence over the last two decades has indicated that the pathophysiology of Major Depressive Disorder (MDD) and the action of antidepressants both involve Brain-Derived Neurotrophic Factor (BDNF), a major neuronal growth factor in the brain. MDD is a complex disorder that results from genetic and environmental influences, singly or in combination. This article reviews the current kn...
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Objective There is increasing evidence that BrainDerived Neurotrophic Factor may be involved in the pathophysiology of depression and the actions of antidepressants. At the same time, the differential diagnosis between unipolar and bipolar depression is often a challenge with important treatment implications. The aim of the present study was to analyze the relationship between BrainDerived Neur...
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ژورنال
عنوان ژورنال: Neuropsychiatric Disease and Treatment
سال: 2009
ISSN: 1176-6328
DOI: 10.2147/ndt.s5700